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Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility

8 Apr 2010

Abstract excerpt

The process of fertilization is critically dependent on the mutual recognition of gametes and in Plasmodium, the male gamete surface protein P48/45 is vital to this process. This protein belongs to a family of 10 structurally related proteins, the so called 6-cys family. To identify the role of additional members of this family in Plasmodium fertilisation, we performed genetic and functional analysis on the five...

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PMID: 20386715
DOI: 10.1371/journal.ppat.1000853

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