Article
Genomic instability in human lymphoid cells exposed to 1 GeV/amu Fe ions.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) - 1 Jan 2001
Grosovsky A, Bethel H, Parks K, Ritter L, Giver C, Gauny S, Wiese C, Kronenberg A
Abstract excerpt
The goal of this study was to assess whether charged particle radiations of importance to spaceflight elicit genomic instability in human TK6 lymphoblasts. The incidence of genomic instability in TK6 cells was assessed ~21 days after exposure to 2, 4, or 6 Fe ions (1 GeV/amu, LET= 146 keV/micrometers). Three indices of instability were used: intraclonal karyotypic heterogeneity, mutation rate analysis at the...
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