Article
Virulence of group A streptococci in fertile hens eggs is mainly effected by M protein and streptolysin O.
International journal of medical microbiology : IJMM - 1 Apr 2001
Schmidt K H, Gerlach D, Gubbe K, Geyer A, Birch-Hirschfeld E, Straube E, Podbielski A
Abstract excerpt
In this study we have investigated whether streptolysin O contributes to the virulence of group A streptococci. For this purpose we generated M-negative and SLO-negative mutants by insertion mutagenesis into the chromosome of an M type 1 strain. The inactivation of M1 protein expression was achieved by the construction of the integrative plasmid pSFABS, which contains the internal fragment abs of the emm1 gene....
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