Inactivation of single genes within the virulence regulon of an M2 group A streptococcal isolate result in differences in virulence for chicken embryos and for mice.

Abstract excerpt

An M2 streptococcal isolate and isogenic mutants in which either the emm or mrp gene was insertionally inactivated were tested for virulence using either a mouse model or a chicken embryo model. The results of the studies using the mouse model demonstrated that neither the emm nor mrp gene products had a significant effect on virulence when mice were challenged via the i.p. route. However, when the bacteria were...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacterial Outer Membrane Proteins
• Share to Bacterial Proteins