Article
Inactivation of single genes within the virulence regulon of an M2 group A streptococcal isolate result in differences in virulence for chicken embryos and for mice.
Microbial pathogenesis - 1 Dec 1997
Schmidt K H, Podbielski A, Raeder R, Boyle M D
Abstract excerpt
An M2 streptococcal isolate and isogenic mutants in which either the emm or mrp gene was insertionally inactivated were tested for virulence using either a mouse model or a chicken embryo model. The results of the studies using the mouse model demonstrated that neither the emm nor mrp gene produc...
Topics
- Animals
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Carrier Proteins
- Chick Embryo
- DNA, Bacterial
- Fibrinogen
- Immunoglobulin A
- Immunoglobulin G
- Injections, Intraperitoneal
- Injections, Subcutaneous
- Membrane Proteins
- Mice
- Mutation
- Regulon
- Serum Albumin
- Skin Diseases, Bacterial