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Article

Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology.

Analytical biochemistry - 15 Apr 2001

Markgren P O, Lindgren M T, Gertow K, Karlsson R, Hämäläinen M, Danielson U H

Abstract excerpt

The interaction between HIV-1 protease and inhibitors has been studied with optical biosensor technology. Optimized experimental procedures and mathematical analysis permitted determination of association and dissociation rate constants. A sensor surface with native enzyme was unstable and exhibi...

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Identifiers

PMID: 11401294
DOI: 10.1006/abio.2001.5025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11401294-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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