Article
Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus.
Virology - 25 Oct 1998
Molla A, Vasavanonda S, Kumar G, Sham H L, Johnson M, Grabowski B, Denissen J F, Kohlbrenner W, Plattner J J, Leonard J M, Norbeck D W, Kempf D J
Abstract excerpt
The potency of therapeutic regimens containing human immunodeficiency virus (HIV) protease inhibitors is related to the ability to maintain concentrations of drug in the plasma of patients that are sufficient for blocking viral replication. The estimation of concentrations required for in vivo ac...
Topics
- Blood Proteins
- Cell Line, Transformed
- HIV Protease Inhibitors
- HIV-1
- Humans
- Lopinavir
- Mutation
- Pyrimidinones
- Ritonavir