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Article

Binding kinetics of highly mutated HIV-1 subtype C protease inhibition by Lopinavir and Darunavir in the face of altered conformational dynamics.

Journal of biomolecular structure & dynamics - 1 Apr 2026

Eche Simeon, Kumar Ajit, Sonela Nelson, Gordon Michelle L

Abstract excerpt

Highly mutated HIV-1 protease (PR) compromises the efficacy of lopinavir (LPV) and darunavir (DRV) used to formulate salvage regimens in HIV/AIDS management. Here, we report the kinetics of inhibition of lopinavir (LPV) and darunavir (DRV) on highly mutated South African HIV-1 subtype C PR obtained from clinical isolates. The wild-type and mutant South African HIV-1 subtype C PR were cloned and purified. Enzyme...

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Darunavir
Drug Resistance, Viral
HIV-1
HIV Protease
HIV Protease Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Dynamics Simulation

Protein Conformation

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PMID: 39697065
DOI: 10.1080/07391102.2024.2426078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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