Article
Racial differences in HLA class II associations with hepatitis C virus outcomes.
The Journal of infectious diseases - 1 Jul 2001
Thio C L, Thomas D L, Goedert J J, Vlahov D, Nelson K E, Hilgartner M W, O'Brien S J, Karacki P, Marti D, Astemborski J, Carrington M
Abstract excerpt
A broad, vigorous CD4 T cell response, mediated by class II human leukocyte antigens (HLAs), favors hepatitis C virus (HCV) clearance. HLA-DQB1*0301 has been associated with viral clearance in an ethnically homogeneous cohort. To validate this association and to identify other class II associations in an ethnically varied cohort, molecular class II HLA typing was performed on 200 HCV clearance and 374 matched...
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