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Article

Disorders linked to insufficient androgen action in male children

1 May 2001

Abstract excerpt

Virilization of the external genitalia in the male fetus requires testosterone and dihydrotestosterone (DHT), which is formed from testosterone by the action of the enzyme, 5alpha-reductase type 2 (5alphaR-2). Mediation of the effects of both testosterone and DHT requires a functional androgen receptor (AR) located in the cytoplasmic compartment of target cells. DHT (or testosterone) binding induces a...

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PMID: 11392378
DOI: 10.1093/humupd/7.3.314

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