Article
Uroplakin as a marker for typing metastatic transitional cell carcinoma on fine-needle aspiration specimens.
Cancer - 25 Jun 2001
Xu X, Sun T T, Gupta P K, Zhang P, Nasuti J F
Abstract excerpt
BACKGROUND: Immunohistological markers specific for a single type of epithelium are rare. Recently, urothelium tissue-specific genes were cloned. The genes encoded a family of transmembrane proteins, uroplakins, that are expressed only in urothelial mucosa. Using uroplakin antibodies on paraffin-embedded tissue, a previous study demonstrated positive staining in 66% of metastatic transitional cell carcinoma (TCC)...
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