Article
Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study.
International journal of cancer - 20 Aug 2002
Kocher Thomas, Zheng Min, Bolli Martin, Simon Ronald, Forster Thomas, Schultz-Thater Elke, Remmel Eugenia, Noppen Christoph, Schmid Ulrico, Ackermann Daniel, Mihatsch Michael J, Gasser Thomas, Heberer Michael, Sauter Guido, Spagnoli Giulio C
Abstract excerpt
TAAs of the MAGE family are mostly studied as targets of specific immune responses. Their potential relevance as tumor markers has also been underlined. We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples from 1,849 patients. In 2,090/2,317 cases (90.2%), immunostaining yielded interpretable results....
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