Protracted, But Not Acute, Hepatitis A Virus Infection Is Strongly Associated With Hla–Drb1*1301, A Marker for Pediatric Autoimmune Hepatitis

Abstract excerpt

HLA alleles are known to be associated with susceptibility to develop autoimmune hepatitis (AH), and hepatitis A virus (HAV) infection is postulated as a putative trigger for AH. We investigated whether HLA may influence the outcome of the HAV infection by studying 67 children with self-limited and 39 children with protracted forms of this infection. HLA typing of the uncomplicated forms showed no significant...

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