Article
Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection.
Hepatology (Baltimore, Md.) - 1 Jun 2001
Bassett S E, Guerra B, Brasky K, Miskovsky E, Houghton M, Klimpel G R, Lanford R E
Abstract excerpt
Hepatitis C virus (HCV) infections were evaluated in chimpanzees that had previously cleared HCV and were rechallenged. Animals that had previously cleared HCV infection rapidly cleared homologous and heterologous virus upon rechallenge, indicative of a strong protective immunity. In one animal, sterilizing immunity was observed with regard to viremia, although viral RNA was transiently detected in the liver....
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