Article
Association of calnexin with wild type and mutant AVPR2 that causes nephrogenic diabetes insipidus.
Biochemistry - 12 Jun 2001
Morello J P, Salahpour A, Petäjä-Repo U E, Laperrière A, Lonergan M, Arthus M F, Nabi I R, Bichet D G, Bouvier M
Abstract excerpt
Over 155 mutations within the V2 vasopressin receptor (AVPR2) gene are responsible for nephrogenic diabetes insipidus (NDI). The expression and subcellular distribution of four of these was investigated in transfected cells. These include a point mutation in the seventh transmembrane domain (S315R), a frameshift mutation in the third intracellular loop (804delG), and two nonsense mutations that code for AVPR2...
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