Article
Molecular and cellular defects in nephrogenic diabetes insipidus.
Pediatric nephrology (Berlin, Germany) - 1 Dec 2001
Knoers N V, Deen P M
Abstract excerpt
The identification of the different molecular causes of congenital nephrogenic diabetes insipidus (NDI), a disorder characterized by renal insensitivity to the antidiuretic effect of arginine vasopressin, has been of indispensable importance for understanding the cellular processes involved in diuresis and antidiuresis. In most cases, NDI is X-linked and caused by mutations in the vasopressin type-2 receptor...
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