Article
Interleukin 2 gene therapy for prostate cancer: phase I clinical trial and basic biology.
Human gene therapy - 20 May 2001
Belldegrun A, Tso C L, Zisman A, Naitoh J, Said J, Pantuck A J, Hinkel A, deKernion J, Figlin R
Abstract excerpt
Twenty-four patients with locally advanced prostate cancer (CaP) were enrolled in a phase I clinical trial using gene-based immunotherapy. A functional DNA-lipid complex encoding the interleukin 2 (IL-2) gene (Leuvectin; Vical, San Diego, CA) was administered intraprostatically into the hypoecogenic tumor lesion, using transrectal ultrasound guidance. Two groups of patients having locally advanced tumors were...
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