Article
The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts.
Molecular pathology : MP - 1 Jun 2001
Leask A, Sa S, Holmes A, Shiwen X, Black C M, Abraham D J
Abstract excerpt
Although the role of transforming growth factor beta (TGFbeta) in initiating fibrosis is well established, the role that TGFbeta plays in maintaining fibrosis is unclear. The gene encoding connective tissue growth factor (ccn2; ctgf), which promotes fibrosis, is not normally expressed in dermal fibroblasts unless TGFbeta is present. However, in dermal fibroblasts cultured from lesional areas of scleroderma, ccn2...
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