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Article

HIV type 1 Nef promotes neoplastic transformation of immortalized neural cells.

AIDS research and human retroviruses - 1 May 2001

Kramer-Hämmerle S, Kohleisen B, Hohenadl C, Shumay E, Becker I, Erfle V, Schmidt J

Abstract excerpt

To study the effects of HIV-1 Nef on CNS-derived cells in vivo, an expression system based on the murine neural stem cell line C17.2 was established. Stable expression of LAV-1(Bru)-nef in these cells induced a transformed phenotype and enhanced cell growth in soft agar. Further experiments using previously established nef-expressing human astrocytoma cell lines as well as nef-expressing murine fibroblasts...

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Identifiers

PMID: 11375055
DOI: 10.1089/088922201300119699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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