Article
The C terminus of annexin II mediates binding to F-actin.
The Journal of biological chemistry - 16 Feb 2001
Filipenko N R, Waisman D M
Abstract excerpt
Annexin II heterotetramer (AIIt) is a multifunctional Ca(2+)-binding protein composed of two 11-kDa subunits and two annexin II subunits. The annexin II subunit contains the binding sites for anionic phospholipids, heparin, and F-actin, whereas the p11 subunit provides a regulatory function. The F-actin-binding site is presently unknown. In the present study we have utilized site-directed mutagenesis to create...
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