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Article

Phosphate wasting in oncogenic osteomalacia: PHEX is normal and the tumor-derived factor has unique properties.

Bone - 1 Apr 2001

Nelson A E, Hogan J J, Holm I A, Robinson B G, Mason R S

Abstract excerpt

Oncogenic osteomalacia (OOM) is characterized by renal phosphate wasting and abnormal metabolism of vitamin D, somewhat similar to the phenotype of X-linked hypophosphatemic rickets (HYP). DNA from OOM tumor cells was analyzed for mutations in the PHEX gene, which is mutated in HYP. Screening for mutations by single-strand conformation polymorphism analysis and subsequent sequencing of all the exons revealed no...

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Source

Identifiers

PMID: 11336925
DOI: 10.1016/s8756-3282(01)00417-3

Genes

PHEX
PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Phosphate wasting in oncogenic osteomalacia: PHEX is normal and the tumor-derived factor has unique properties.PMID 11336925Read ↗

Oncogenic osteomalacia: is there a new phosphate regulating hormone?Semantic proximity Read ↗

Coordinated maturational regulation of PHEX and renal phosphate transport inhibitory activity: evidence for the pathophysiological role of PHEX in X-linked hypophosphatemia.Semantic proximity Read ↗

FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate.Semantic proximity Read ↗

The Autosomal Dominant Hypophosphatemic Rickets (ADHR) Gene Is a Secreted Polypeptide Overexpressed by Tumors that Cause Phosphate WastingSemantic proximity Read ↗

Developmental Expression and Tissue Distribution of Phex Protein: Effect of the <i>Hyp</i> Mutation and Relationship to Bone MarkersSemantic proximity Read ↗

PHEX gene and hypophosphatemia.Semantic proximity Read ↗

FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.Semantic proximity Read ↗

Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.Semantic proximity Read ↗

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A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells.Semantic proximity Read ↗

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

Osteocyte-Specific Monoclonal Antibody MAb OB7.3 Is Directed Against Phex ProteinSemantic proximity Read ↗

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