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Article

Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.

The Journal of biological chemistry - 12 Aug 2016

Wadas Brandon, Borjigin Jimo, Huang Zheping, Oh Jang-Hyun, Hwang Cheol-Sang, Varshavsky Alexander

Abstract excerpt

Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep. N-terminal sequences of AANAT enzymes vary among vertebrates. Mechanisms that regulate the levels of AANAT are incompletely understood. Previous findings were consistent with the...

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Source

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Identifiers

PMID: 27339900
DOI: 10.1074/jbc.M116.734640
PMCID: PMC5016120

Genes

AANAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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