Article
Evolution of arylalkylamine N-acetyltransferase: emergence and divergence.
Molecular and cellular endocrinology - 27 Jun 2006
Coon Steven L, Klein David C
Abstract excerpt
The melatonin rhythm-generating enzyme, arylalkylamine N-acetyltransferase (AANAT) is known to have recognizable ancient homologs in bacteria and fungi, but not in other eukaryotes. Analysis of new cDNA and genomic sequences has identified several additional homologs in other groupings. First, an AANAT homolog has been found in the genome of the cephalochordate amphioxus, representing the oldest homolog in...
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