Article
Etiology of differences in hematocrit between males and females: sequence-based polymorphisms in erythropoietin and its receptor.
The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia - 1 Jan 2001
Zeng S M, Yankowitz J, Widness J A, Strauss R G
Abstract excerpt
INTRODUCTION: Males have a higher hematocrit (Hct) than females. The cause of this gender-based difference is unclear. We sought to determine whether polymorphisms of the erythropoietin (EPO) gene or of its receptor (EPOR) explain this situation. METHODS: We designed primers for the EPO and EPOR genes. Previously undescribed polymorphisms were found based on band migration on polyacrylamide gel, and when then...
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