Article
Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2001
Inoue N, Dong R, Hirata R K, Russell D W
Abstract excerpt
Adeno-associated virus (AAV) vectors can modify homologous chromosomal sequences at high rates. This gene targeting transduction pathway is distinct from the integrating and episomal pathways used in gene addition approaches. In previous studies, AAV vectors were used to introduce small insertion and deletion mutations at homologous chromosomal loci. Here we show that AAV-mediated gene targeting can also be used...
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