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Article

Stimulation of new bone formation by direct transfer of osteogenic plasmid genes.

11 Jun 1996

Abstract excerpt

Degradable matrices containing expression plasmid DNA [gene-activated matrices (GAMs)] were implanted into segmental gaps created in the adult rat femur. Implantation of GAMs containing beta-galactosidase or luciferase plasmids led to DNA uptake and functional enzyme expression by repair cells (granulation tissue) growing into the gap. Implantation of a GAM containing either a bone morphogenetic protein-4 plasmid...

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Identifiers

PMID: 8650165
DOI: 10.1073/pnas.93.12.5753

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