Article
Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis.
Oncogene - 18 Jan 2001
Kim K W, Chung H H, Chung C W, Kim I K, Miura M, Wang S, Zhu H, Moon K D, Rha G B, Park J H, Jo D G, Woo H N, Song Y H, Kim B J, Yuan J, Jung Y K
Abstract excerpt
Caspase plays an important role in apoptosis. We report here that farnesyltransferase/geranylgeranyltransferase (FTase/GGTase)-alpha, a common subunit of FTase (alpha/beta(FTase)) and GGTase I (alpha/beta(GGTase)), was cleaved by caspase-3 during apoptosis. FTase/GGTase-alpha (49 kDa) was cleaved to 35 kDa (p35) in the Rat-2/H-ras, W4 and Rat-1 cells treated with FTase inhibitor (LB42708), anti-Fas antibody and...
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