Article
Effect of alosetron on the pharmacokinetics of fluoxetine.
Journal of clinical pharmacology - 1 Apr 2001
D'Souza D L, Dimmitt D C, Robbins D K, Nezamis J, Simms L, Koch K M
Abstract excerpt
Lotronex (alosetron hydrochloride) is a 5-HT3 receptor antagonist indicated for the treatment of irritable bowel syndrome (IBS) in females whose predominant bowel habit is diarrhea. Alosetron is extensively metabolized by multiple cytochrome P450 (CYP) enzymes, including CYP2C9 and CYP3A4. Fluoxetine is an antidepressant that is administered as a racemic mixture of equipotent R- and S-enantiomers. Fluoxetine...
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