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Article

Concentrations of Fluoxetine Enantiomers Decline During Pregnancy and Increase After Birth.

Journal of clinical psychopharmacology - 1 Jan 2000

Wisner Katherine L, Avram Michael J, George Alfred L, Abramova Tatiana V, Yang Amy, Caritis Steve N, Costantine Maged M, Stika Catherine S

Abstract excerpt

RATIONALE: Few studies of the effect of the dynamic physiologic changes during pregnancy on plasma concentrations of fluoxetine (FLX) have been published. OBJECTIVES: We determined the change in concentration to dose (C/D) ratios of R- and S-FLX and R- and S-norfluoxetine monthly during pregnancy and postpartum, assessed their relationships to cytochrome P450 (CYP) 2D6 and CYP2C9 metabolizer phenotypes, and...

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Identifiers

PMID: 38421920
DOI: 10.1097/JCP.0000000000001821
PMCID: PMC10906734

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