Article
[Abnormalities of the p53, N-ras, DCC and FLT-3 genes in myelodysplastic syndromes].
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi - 1 Apr 2001
Nakamura K, Inokuchi K, Dan K
Abstract excerpt
The molecular mechanism of carcinogenesis is a multistep process that is characterized by both activation of oncogenes and inactivation of tumor suppressor genes. In the present study, mutations of N-ras, p53 and FMS-like tyrosine kinase 3 (FLT-3) genes and loss of expression of the deleted in colorectal carcinoma (DCC) gene were analyzed in 59 patients with myelodysplastic syndromes (MDS). Mutations of N-ras,...
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