Article
Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA.
The Journal of biological chemistry - 2 Jun 2006
Lu Ling, Ma Yueyun, Zhang Jing-Ren
Abstract excerpt
Streptococcus pneumoniae, a human pathogen, is naturally capable of colonizing the upper airway and sometimes disseminating to remote tissue sites. Previous studies have shown that S. pneumoniae is able to evade complement-mediated innate immunity by recruiting complement factor H (FH), a complement alternative pathway inhibitor. Pneumococcal binding to FH has been attributed to choline-binding protein A (CbpA)...
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