Article
Polymorphism of the 5'-upstream region of the human SNAP-25 gene: an association analysis with schizophrenia.
Neuropsychobiology - 1 Jan 2001
Tachikawa H, Harada S, Kawanishi Y, Okubo T, Suzuki T
Abstract excerpt
Recent studies have suggested that synaptic abnormalities may be part of the pathophysiology of schizophrenia. SNAP-25 (synaptosomal-associated protein of 25 kD) is one of the synaptic proteins responsible for presynaptic neurotransmission, axonal elongation and synaptogenesis. Genetic variation in the 5'-upstream region of the SNAP-25 gene was analyzed in 87 unrelated schizophrenic patients and 100 healthy...
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