Article
Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder.
American journal of medical genetics - 8 Apr 2002
Mill Jonathan, Curran Sarah, Kent Lindsey, Gould Alison, Huckett Louise, Richards Sandra, Taylor Eric, Asherson Philip
Abstract excerpt
Several lines of evidence implicate synaptosomal-associated protein of 25 kDa (SNAP-25) in the etiology of attention deficit hyperactivity disorder (ADHD). Most notably, the coloboma mouse mutant, considered to be a good animal model of hyperactivity, has a deletion spanning this gene. Introducing a SNAP-25 transgene into these animals alleviates hyperlocomotion. We have identified a novel microsatellite repeat...
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