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Article

The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.

Cancer research - 1 Mar 2001

Cohen-Jonathan E, Evans S M, Koch C J, Muschel R J, McKenna W G, Wu J, Bernhard E J

Abstract excerpt

Many tumors contain extensive regions of hypoxia. Because hypoxic cells are markedly more resistant to killing by radiation, repeated attempts have been made to improve the oxygenation of tumors to enhance radiotherapy. We have studied the oxygenation of tumor xenografts in nude mice after treatm...

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PMID: 11280800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11280800-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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