Article
Augmented antitumor effects of radiation therapy by 4-1BB antibody (BMS-469492) treatment.
Anticancer research - 1 Jan 2000
Shi Wenyin, Siemann Dietmar W
Abstract excerpt
BACKGROUND: 4-1BB (CD137) is a member of the tumor necrosis factor receptor superfamily. It interacts with 4-1BB ligand (4-1BBL) and delivers a costimulatory signal for T cell activation. The immune response induced by 4-1BB monoclonal antibodies (mAbs) has been shown to have a marked augmentatio...
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