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Effect Of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle

13 Mar 2001

Abstract excerpt

We report here that the DNA-dependent protein kinase (DNA-PK) affects the molecular fate of the recombinant adeno-associated virus (rAAV) genome in skeletal muscle. rAAV-human alpha1-antitrypsin (rAAV-hAAT) vectors were delivered by intramuscular injection to either C57BL/6 (DNA-PKcs(+)) or C57BL/6-SCID [severe combined immunodeficient (SCID), DNA-PKcs(-)] mice. In both strains, high levels of transgene...

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PMID: 11274433
DOI: 10.1073/pnas.061014598

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