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Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle

10 Feb 2004

Abstract excerpt

BACKGROUND: Although the transient nature of transgene expression using first-generation adenovirus (Ad) vectors is well known, the exact mechanisms responsible for this phenomenon are uncertain. METHODS: Rats were given intramuscular (i.m.) injections of a first-generation Ad containing the human fibroblast growth factor 4 (hFGF-4) gene driven by the cytomegalovirus (CMV) promoter and enhancer (CMV-PE). The copy...

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PMID: 15079814
DOI: 10.1002/jgm.516

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