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Article

Structure of Adeno-Associated Virus Vector DNA following Transduction of the Skeletal Muscle

1 Mar 1999

Abstract excerpt

The skeletal muscle provides a very permissive physiological environment for adeno-associated virus (AAV) type 2-mediated gene transfer. We have studied the early steps leading to the establishment of permanent transgene expression, after injection of recombinant AAV (rAAV) particles in the quadriceps muscle of mice. The animals received an rAAV encoding a secreted protein, murine erythropoietin (mEpo), under the...

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PMID: 9971774
DOI: 10.1128/jvi.73.3.1949-1955.1999

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