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Article

Localization of the APECED protein in distinct nuclear structures

1 Feb 1999

Abstract excerpt

Autoimmune-polyendocrinopathy-candidiasis-ecto-dermaldystrophy (APECED) is the only systemic autoimmune disease with a monogenic background known so far revealing no association with the major histocompatibility complex region. We have recently isolated the gene defective in this syndrome and characterized several different mutations in individuals with the disorder. The novel gene, AIRE, contains a putative...

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Identifiers

PMID: 9931333
DOI: 10.1093/hmg/8.2.259

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Localization of the APECED protein in distinct nuclear structuresPMID 9931333Read ↗

Cloning of the APECED gene provides new insight into human autoimmunity.Semantic proximity Read ↗

AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers.Semantic proximity Read ↗

Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein.Semantic proximity Read ↗

Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targetingSemantic proximity Read ↗

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains.Semantic proximity Read ↗

APECED-causing mutations in AIRE reveal the functional domains of the protein.Semantic proximity Read ↗

Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED).Semantic proximity Read ↗

The autoimmune regulator: a key toward understanding the molecular pathogenesis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.Semantic proximity Read ↗

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouseSemantic proximity Read ↗

Characterization of Regulatory Elements and Methylation Pattern of the Autoimmune Regulator (AIRE) PromoterSemantic proximity Read ↗

The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factorSemantic proximity Read ↗

Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.Semantic proximity Read ↗

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