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Article

Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM.

Molecular cancer research : MCR - 1 Dec 2003

Bai Yongli, Murnane John P

Abstract excerpt

Nijmegen breakage syndrome (NBS) is an autosomal genetic disease demonstrating a variety of phenotypic abnormalities, including premature aging, increased cancer incidence, chromosome instability, and sensitivity to ionizing radiation. The gene involved in NBS, NBS1, is part of the MRE11/RAD50/NBS1 (MRN) complex that also includes MRE11 and RAD50, which is involved in DNA repair and cell cycle regulation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14707289

Genes

ATM
MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM.PMID 14707289Read ↗

NBS1 Knockdown by Small Interfering RNA Increases Ionizing Radiation Mutagenesis and Telomere Association in Human CellsSemantic proximity Read ↗

Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.Semantic proximity Read ↗

Nijmegen Breakage Syndrome (NBS) is a Telomeropathy: Analysis of Telomere Length in NBS Homo- and Heterozygotes and Humanized Nbs MiceSemantic proximity Read ↗

The NBS1-ATM Connection RevisitedSemantic proximity Read ↗

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosisSemantic proximity Read ↗

Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunitSemantic proximity Read ↗

A murine model of Nijmegen breakage syndrome.Semantic proximity Read ↗

Disruption of Telomere Maintenance by Depletion of the MRE11/RAD50/NBS1 Complex in Cells That Use Alternative Lengthening of TelomeresSemantic proximity Read ↗

NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2 Phases in Immortalized Telomerase-negative CellsSemantic proximity Read ↗

A case report of a patient with microcephaly, facial dysmorphism, chromosomal radiosensitivity and telomere length alterations closely resembling "Nijmegen breakage syndrome" phenotype.Semantic proximity Read ↗

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.Semantic proximity Read ↗

New mutations and protein variants of NBS1 are identified in cancer cell lines.Semantic proximity Read ↗

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