Article
Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians.
Biochimica et biophysica acta - 19 Mar 2001
Thameem F, Wolford J K, Bogardus C, Prochazka M
Abstract excerpt
The human proto-oncogene PBX1 codes for a homeodomain containing protein that modulates expression of several genes, including those contributing to regulation of insulin action and glucose metabolism. PBX1 is located on chromosome 1q22, a region linked with type 2 diabetes in Pima Indians, Caucasians, and an Old Order Amish population. We have investigated the PBX1 genomic sequence to identify polymorphisms that...
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