Article
Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure.
Protein science : a publication of the Protein Society - 1 Jan 2001
Mangione P, Sunde M, Giorgetti S, Stoppini M, Esposito G, Gianelli L, Obici L, Asti L, Andreola A, Viglino P, Merlini G, Bellotti V
Abstract excerpt
We recently described a new apolipoprotein A1 variant presenting a Leu174Ser replacement mutation that is associated with a familial form of systemic amyloidosis displaying predominant heart involvement. We have now identified a second unrelated patient with very similar clinical presentation and carrying the identical apolipoprotein A1 mutation. In this new patient the main protein constituent of the amyloid...
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