Article
International perspectives on antiretroviral resistance. Nucleoside reverse transcriptase inhibitor resistance.
Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2001
Loveday C
Abstract excerpt
Nucleoside reverse transcriptase inhibitors (NRTIs) comprise the first class of drug with proven antiretroviral efficacy against HIV-1, and the first in which drug resistance was reported. Ongoing research in the area of NRTI resistance and cross-resistance contributes much to what we know about the failure of antiretroviral therapy. The genetic mutation patterns responsible for resistance to the available NRTIs...
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