Article
Increased risk of malignant progression in benign proliferating breast lesions defined by expression of heat shock protein 27.
British journal of cancer - 12 Jan 2004
O'Neill P A, Shaaban A M, West C R, Dodson A, Jarvis C, Moore P, Davies M P A, Sibson D R, Foster C S
Abstract excerpt
Heat shock protein 27 (hsp-27) is a regulator of oestrogen receptor (ER) expression and a modulator of intracellular homeostasis. In this laboratory, Shaaban et al demonstrated the importance of ER-alpha, together with Ki67, in enhancing the progression of benign breast lesions of defined morphological types. To better understand the mechanisms by which ER-alpha promotes breast neoplasia, this study was performed...
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