Article
A pharmacogenomic approach to Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum - 1 Jan 2000
Cacabelos R, Alvarez A, Fenández-Novoa L, Lombardi V R
Abstract excerpt
Single nucleotide polymorphisms (susceptibility genetics) and genomic point mutations (mendelian genetics) can be used in Alzheimer's disease (AD) for diagnostic, predictive and therapeutic purposes. Using a matrix genetic model, including APOE, PS1 and PS2 allelic variants, we have studied the distribution of 36 different genotypes in the AD population (N= 479) and the genotype-related cognitive response to a...
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