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Article

Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles.

Infection and immunity - 1 Sept 2002

Baudner B C, Balland O, Giuliani M M, Von Hoegen P, Rappuoli R, Betbeder D, Del Giudice G

Abstract excerpt

Most vaccines are still given parenterally. Mucosal vaccination would offer different advantages over parenteral immunization, including blocking of the pathogens at the portal of entry. In this paper, nontoxic Escherichia coli heat-labile enterotoxin (LT) mutants and Supramolecular Biovector systems (SMBV) were evaluated in mice as mucosal adjuvants and delivery systems, respectively, for intranasal immunization...

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Topics

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Share to Adjuvants, Immunologic
Share to Administration, Intranasal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Bacterial

Share to Bacterial Toxins

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Share to Immunity, Mucosal

Share to Meningococcal Vaccines

Share to Neisseria meningitidis

Source

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Identifiers

PMID: 12183520
DOI: 10.1128/IAI.70.9.4785-4790.2002
PMCID: PMC128246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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