Article
"Other" breast cancer susceptibility genes: searching for more holy grail.
Human molecular genetics - 1 Apr 2001
Nathanson K L, Weber B L
Abstract excerpt
While germline mutations in BRCA1 and BRCA2 account for most, if not all families with autosomal dominant transmission of susceptibility to both breast and ovarian cancer, it has become clear that together these genes only account for a small proportion of hereditary site-specific breast cancer susceptibility. However, difficulties due to genetic heterogeneity, reduced penetrance and perhaps gene mutation...
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