Article
Reduced virulence of a Bordetella bronchiseptica siderophore mutant in neonatal swine.
Infection and immunity - 1 Apr 2001
Register K B, Ducey T F, Brockmeier S L, Dyer D W
Abstract excerpt
One means by which Bordetella bronchiseptica scavenges iron is through production of the siderophore alcaligin. A nonrevertible alcaligin mutant derived from the virulent strain 4609, designated DBB25, was constructed by insertion of a kanamycin resistance gene into alcA, one of the genes essential for alcaligin biosynthesis. The virulence of the alcA mutant in colostrum-deprived, caesarean-delivered piglets was...
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