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Article

Evidence for a reduced effect of chloroquine against Plasmodium falciparum in alpha-thalassaemic children.

Tropical medicine & international health : TM & IH - 1 Feb 2001

Mockenhaupt F P, May J, Bergqvist Y, Meyer C G, Falusi A G, Bienzle U

Abstract excerpt

Alpha-thalassaemia is common in malaria-endemic regions and is considered to confer protection from clinical disease due to infection with Plasmodium falciparum. In vitro, sensitivity to chloroquine (CQ) of P. falciparum infecting alpha-thalassaemic erythrocytes is reduced. We examined, in a cross-sectional study of 405 Nigerian children, associations between alpha-globin genotypes, blood concentrations of CQ,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11251905
DOI: 10.1046/j.1365-3156.2001.00688.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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