Article
Aldosterone synthase (CYP11B2) gene polymorphism and cerebral white matter hyperintensities.
Neurology - 13 Mar 2001
Verpillat P, Alpérovitch A, Cambien F, Besançon V, Desal H, Tzourio C
Abstract excerpt
The association between aldosterone synthase (CYP11B2) gene polymorphism and white matter hyperintensities seen on cerebral MRI was studied in a population-based sample of 829 individuals aged 63 to 75 years. The T allele was associated with the risk of severe white matter hyperintensities. Compared with the CC genotype, the adjusted OR for severe white matter hyperintensities was 4.61 (95% CI, 1.46 to 14.55) for...
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