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Article

Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis.

Endocrine - 1 Jun 1997

Almeida M R, Damas A M, Lans M C, Brouwer A, Saraiva M J

Abstract excerpt

The majority of the known transthyretin (TTR) variants are associated with amyloidosis, but there are also variants associated with euthyroid hyperthyroxinemia and others are apparently nonpathogenic. TTR Met 119 is a nonpathogenic variant found to be frequent in the Portuguese population. Previous studies on thyroxine (T4) binding to semi-purified TTR from heterozygotic carriers of TTR Met 119, reported by us...

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Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9368688
DOI: 10.1007/BF02820508

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis.PMID 9368688Read ↗

Thyroxine binding in a TTR Met 119 kindred.Semantic proximity Read ↗

Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution.Semantic proximity Read ↗

Thyroxine binding by human transthyretin variants: mutations at position 119, but not position 54, increase thyroxine binding affinity.Semantic proximity Read ↗

A novel variant of transthyretin (prealbumin), Thr119 to Met, associated with increased thyroxine binding.Semantic proximity Read ↗

Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.Semantic proximity Read ↗

Comparative stability and clearance of [Met30]transthyretin and [Met119]transthyretin.Semantic proximity Read ↗

Screening and biochemical characterization of transthyretin variants in the Portuguese population.Semantic proximity Read ↗

Thyroxine binding to transthyretin (TTR) variants--two variants (TTR Pro 55 and TTR Met 111) with a particularly low binding affinity.Semantic proximity Read ↗

Enhanced transthyretin tetramer stability following expression of an amyloid disease transsuppressor variant in mammalian cells.Semantic proximity Read ↗

From molecular variant to disease: initial steps in evaluating the association of transthyretin M119 with disease.Semantic proximity Read ↗

Modulating conformational factors in transthyretin amyloid.Semantic proximity Read ↗

A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study.Semantic proximity Read ↗

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