Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis.

doi:10.1007/BF02820508

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Article

Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis.

Endocrine - 1 Jun 1997

Almeida M R, Damas A M, Lans M C, Brouwer A, Saraiva M J

Abstract excerpt

The majority of the known transthyretin (TTR) variants are associated with amyloidosis, but there are also variants associated with euthyroid hyperthyroxinemia and others are apparently nonpathogenic. TTR Met 119 is a nonpathogenic variant found to be frequent in the Portuguese population. Previo...

Topics

Binding, Competitive
Crystallography, X-Ray
Heterozygote
Humans
Iodine Radioisotopes
Methionine
Mutation
Prealbumin
Protein Binding
Recombinant Proteins
Thyroxine

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